A Review of Atomic-Force Microscopy in Skin Barrier Function Assessment
Scientific PublicationsA Review of Atomic-Force Microscopy in Skin Barrier Function Assessment
Journal of Investigative Dermatology, 143(10), June 2024
Skin barrier disorders like atopic dermatitis affect millions, causing itch, discomfort, and reduced quality of life. Traditional diagnostics often rely on subjective symptoms, which can be imprecise. This review explains how atomic-force microscopy (AFM) revolutionizes skin analysis by zooming in at the nanoscale. Using noninvasive tape-stripping, AFM examines corneocytes to reveal surface patterns (nanotextures) linked to disease severity, hydration levels, and even genetics. Loretta’s compact HS-DAFM makes this technology more accessible, moving it from labs to clinics. Overall, AFM offers a precise, quantitative tool for better diagnosis, treatment tracking, and personalized skin care.
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